Myriocin

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Myriocin
Chemical formula	C21H39NO6
Molecular mass	401.54 g/mol
CAS number	[35891-70-4]
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Myriocin, also known as Antibiotic ISP-1, Thermozymocidin, is an atypic amino acid, an antibiotic derived from certain thermophylic fungi. Among the producing strains are: Mycelia sterilia, Isaria sinclairii,

Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingolipid biosynthesis. Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids.

Myriocin was shown to inhibit the proliferation of an IL-2-dependent mouse cytotoxic T cell line.

Myriocin possesses immunosuppressant activity. It is reported to be 10 to 100 fold more potent than cyclosporin.

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