Mycobacterium lepraemurium
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| Mycobacterium lepraemurium Marchoux and Sorel 1912 |
Mycobacterium lepraemurium is the causative agent of feline leprosy. It causes granulomatous lesions, characteristic of the Mycobacterium genus.
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[edit] Description
Gram-positive, nonmotile and strongly acid-fast rods (3-5µm long). Slightly rounded ends.
Colony characteristics
- Rough nonchromogenic colonies.
Physiology
- Growth on inspissated 1% egg yolk medium at 30°C - 37°C within 4-5 weeks (using large inocula, confined to a concentrated area of the medium, egg white is inhibitory).
[edit] Pathogenesis
- Cause of endemic disease of rats in various parts of the world, as well as feline leprosy.
- feline leprosy is transmitted by bites from rats and other cats.
- Disease occurs mainly in the skin and lymph nodes, causing induration, alopecia and eventual ulceration.
- Nodular lesions, involving subcutaneous tissues, may be solitary or multiple and usually confined to the head region or the limbs. Nodules are fleshy and freely movable.
- Surgical excision of the lesions is the preferred treatment.
- Only the densely and uniformly stained forms appear to be infectious for animals, in contrast to the degenerate unevenly stained forms.
[edit] Type Strain
None specified due to difficulties in cultivation.
[edit] References
- Marchoux,F., E. Sorel. 1912. Recherches sur la lèpre. Annales de l'Institut Pasteur (Paris), 26, 675-700.
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