Muller glia
From Wikipedia, the free encyclopedia
Müller glia, or Müller cells, are glia found in the vertebrate retina, which normally serve the functions of any normal glial cells. However, following injury to the retina, it has been seen that Müller glia actually de-differentiate into a neural progenitor. At this point it can act as a stem cell and differentiate into different retinal neurons, including photoreceptors that may have been damaged during injury.
[edit] Research Potential
Müller glia are currently being studied in labs all over the United States as they are involved in neural regeneration, a phenomenon that does not occur in humans. Published papers have studied Müller glia in both zebrafish[1] and chicken[2] retina, and further research could help towards solutions for the blind or visually impaired.
[edit] External links
- Müller cells
- The Muller (glial) cell in normal and diseased retina: a case for single-cell electrophysiology.
[edit] References
- ^ Fausett, BV and Goldman, D. A role for a1 tubulin-expressing Muller glia in regeneration of the injured zebrafish retina. J. Neurosci. 26: 6303-6313, 2006; Raymond, PA, et al. Molecular characterization of retinal stem cells and their niches in adult zebrafish. BMC Dev Biol. Volume: 6, Issue: 2006, Date: 2006 09 12, Pages: 36
- ^ Fischer, AJ. Müller glia are a potential source of neural regeneration in the postnatal chicken retina. Nat Neurosci. Volume: 4, Issue: Mar, Date: 2001 03 06, Pages: 247-52