Mothers against decapentaplegic homolog 7

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SMAD, Mothers against decapentaplegic homolog 7
Solution Structure Of Smurf2 Ww3 Domain-Smad7 Py Peptide Complex
Symbol(s):	SMAD5 hSMAD7, MADH7, MADH8, Smad7, SMAD7
Other names:	Mothers against DPP homolog 7
Genetic data
Locus:	Chr. 18 q21.1{{{LocusSupplementaryData}}}
Gene code:	HUGO code:SMAD7
Protein Structure/Function
Protein type:	I-SMAD
Functions:	signal transduction, transcription
Domains:	MH1, MH2
Other
Taxa expressing:	homo sapiens; homolog: many metazoan phyla
Cell types:	ubiquitous; high levels in vascular endothelium
Subcellular localization:	Primary:nucleus, Alternative:cytoplasm
Covalent modifications:	phosphorylation
Database Links
Entrez:	4092
OMIM:	602932
RefSeq:	NM_005904
UniProt:	O15105

SMAD7 or Mothers against decapentaplegic homolog 7 is a polypeptide that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decepentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of ligands. Like many other TGFβ family members SMAD7 is involved in cell signalling. It is a TGFβ type 1 receptor antagonist. It blocks TGFβ1 and activin associating with the receptor and blocking access to SMAD2. It is an inhibitory SMAD (I-SMAD) and is enhanced by SMURF2.