Montezuma's Revenge
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For other uses see: Montezuma's Revenge (disambiguation)
Montezuma's Revenge (var. Moctezuma's Revenge) refers to Moctezuma II (1466-1520), the emperor of Aztecs at the time of the conquering of the Aztecs by European invaders led by Hernán Cortés (1485-1548). So that anything bad that happens in Mexico to descendants from the invaders, or any non-Mexican, for that matter, could be interpreted as a posthumous "revenge" of the emperor against his enemies.
In contemporary American slang, this term has come to mean travelers' diarrhea suffered by tourists visiting Mexico. See Montezuma's Revenge (medicine).