Monoacylglycerol lipase

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Monoacylglycerol lipase

Monoacylglycerol lipase, also known as MAG lipase, MAGL, MGL or MGLL, is a key enzyme in the hydrolysis of the endocannabinoid 2-arachidonoylglycerol. It converts monoacylglycerols to the free fatty acid and glycerol.

Inhibitors and assay

The enzyme is reported to be inhibited by URB754, however this inhibitor has subsequently been shown to be inactive and its reported activity due to contamination. MGLL activity is commonly assayed by use of the radiolabelled substrate 2-oleoyl-[3H]-glycerol.

[edit] References

  • Karlsson, M., et al. cDNA Cloning, Tissue Distribution, and Identification of the Catalytic Triad of Monoglyceride Lipase. J. Biol. Chem. 1997. (272)43:27218. Article
  • Dinh, T.P., et al. Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc. Nat. Acad. Sci. 2002. (99)16:10819. Article
  • Mkara, J.K., et al. Corrigendum to "Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus". Nat. Neurosci. 2007. (10)1:134. Corrigendum
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