Missouri Route 80
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| Route 80 |
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| Maintained by MoDOT | |||||||||
| Length: | 26 mi (42 km) | ||||||||
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| East end: | Belmont | ||||||||
| West end: | South of Sikeston | ||||||||
| Major cities: | Belmont East Prairie |
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Route 80 is a highway in southeastern Missouri. Its eastern terminus is at the Mississippi River in Belmont; its western terminus is at U.S. Route 61/U.S. Route 62 midway between Sikeston and New Madrid. East Prairie is the only other town on the highway.
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