Metaraminol
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Metaraminol
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| Systematic (IUPAC) name | |
| 3-[(1R,2S)-2-amino-1-hydroxy-propyl]phenol | |
| Identifiers | |
| CAS number | |
| ATC code | C01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C9H13NO2 |
| Mol. mass | 167.205 g/mol |
| Pharmacokinetic data | |
| Bioavailability | n/a |
| Protein binding | ~45% |
| Metabolism | Hepatic |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status | |
| Routes | Intravenous |
Metaraminol (INN, trade name Aramine®) is a potent sympathomimetic amine used in the prevention and treatment of hypotension, particularly as a complication of anesthesia. It is an α1-adrenergic receptor agonist.
Metaraminol is also used in the treatment of priapism. Although not approved for this use, it appears to be effective.[1][2][3]
[edit] References
- ^ McDonald M, Santucci R (2004). "Successful management of stuttering priapism using home self-injections of the alpha-agonist metaraminol.". Int Braz J Urol 30 (2): 121-2. PMID 15703094.
- ^ Koga S, Shiraishi K, Saito Y (1990). "Post-traumatic priapism treated with metaraminol bitartrate: case report.". J Trauma 30 (12): 1591-3. PMID 2258979.
- ^ Block T, Sturm W, Ernst G, Staehler G, Schmiedt E (1988). "[Metaraminol in therapy of various forms of priapism]". Urologe A 27 (4): 225-9. PMID 3140463.
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Dobutamine, Dopamine, Epinephrine, Fenoldopam, Isoprenaline, Metaraminol, Midodrine, Norepinephrine, Octopamine, Phenylephrine
