Metallome
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The term metallome has been introduced by R.J.P. Williams by analogy with proteome as distribution of free metal ions in every one of cellular compartments. Subsequently, the term metallomics has been coined as the study of metallome. Szpunar (2005) defined metallomics as "comprehensive analysis of the entirety of metal and metalloid species within a cell or tissue type". Therefore, metallomics can be considered a branch of metabolomics, even though the metals are not typically considered as metabolites.
Hiroki Haraguchi gave an alternative definition of "metallomes" as metalloproteins or any other metal-containing biomolecules, and "metallomics" as a study of such biomolecules.
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[edit] References
- Williams, R.J.P. (2001). "Chemical selection of elements by cells". Coordination Chemistry Reviews 216–217: 583–595.
- Szpunar, J. (2005). "Advances in analytical methodology for bioinorganic speciation analysis: metallomics, metalloproteomics and heteroatom-tagged proteomics and metabolomics". The Analyst 130: 442–465. PMID 15776152.
- Haraguchi, H. (2004). "Metallomics as integrated biometal science". Journal of Analytical Atomic Spectrometry 19: 5–14.
- Wackett, L.P., Dodge, A.G. and Ellis, L.B.M. (2004). "Microbial genomics and the periodic table". Applied and Environmental Microbiology 70: 647–655. PMID 14766537.
