Mesembrine

Mesembrine

Systematic name	3a-(3,4-Dimethoxyphenyl)octahydro-1-methyl-6H-indol-6-one
Chemical formula	C₁₇H₂₃NO_3</sub
Molecular weight	289.37 g/mol
CAS number	[468-53-1]
SMILES	CN1CCC2(C1CC(=O)CC2)C3=CC(=C(C=C3)OC)OC
Disclaimer and references

Mesembrine, is an alkaloid present in Sceletium tortuosum ^[1]. It has been shown to be an extremely potent serotonin reuptake inhibitor, active at dosages as low as 100μg (micrograms) ^[2]. It has also been shown to be a PDE4-inhibitor ^[3]. Mesembrine may contribute to the antidepressant effects of kanna.

[edit] References

^ Psychoactive constituents of the genus Sceletium N.E.Br. and other Mesembryanthemaceae: a review. [1]
^ Pharmaceutical compositions containing mesembrine and related compounds. U.S. Patent 6,288,104 (PDF)
^ Mesembrine - an inhibitor of PDE4 that follows structure-activity relationship to rolipram. [2]