Meclizine

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Meclizine
Systematic (IUPAC) name
1-[(4-chlorophenyl)- phenyl-methyl]-4- [(3-methylphenyl)methyl]piperazine
Identifiers
CAS number	569-65-3
ATC code	A04AB04 R06AE05
PubChem	4034
DrugBank	APRD00354
Chemical data
Formula	C25H27ClN2
Mol. mass	390.948 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	6 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	B
Legal status
Routes	Oral

Indicated for	Relief of nausea and motion sickness
Recreational	Possible anticholinergic hallucinations.
Contraindications	Alcohol; Clinical studies in children have not been done; usage is not recommended under 12 years of age.
Side effects	Drowsiness

Meclizine (proposed INN is meclozine) is an antihistamine, considered to be an antiemetic. It is most commonly used to inhibit nausea and vomiting. An alternative to dimenhydrinates like Dramamine, Meclizine is considered to perform the same functions at an equitable level of effectiveness, but with reduced side effects.

Contents 1 Uses 1.1 Motion Sickness 1.2 Vertigo 2 Risks of Use 2.1 Drowsiness 2.2 Pregnancy 2.3 Anticholinergics 3 Commercial Names 4 External links

[edit] Uses

[edit] Motion Sickness

Meclizine is effective in inhibiting the symptoms of motion sickness, such as nausea, vomiting, and dizziness.

[edit] Vertigo

Meclizine may be effective in relieving vertigo experienced as a result of inner ear infections or other conditions.

[edit] Risks of Use

[edit] Drowsiness

Drowsiness may result as a side effect of taking Meclizine. While the effects are less than Dramamine, users are advised not to operate heavy machinery while under the influence. The consumption of alcohol while under the influence of Meclizine may result in additional drowsiness.

[edit] Pregnancy

Studies have shown that cleft palates of fetuses were formed when pregnant rats were exposed to 25-50 times a normal dosage. Thus, pregnant women are advised not to take Meclizine unless it is absolutely necessary.

[edit] Anticholinergics

Due to its possible anticholinergic action, Meclizine should be used carefully with patients who suffer from asthma, glaucoma, or an enlarged prostate gland.

[edit] Commercial Names

Meclizine hydrochloride is sold under the commercial names

• Dramamine II®
• Dramamine Less Drowsy®
• Antivert®
• Bonine®
• Bonamine®
• Bonikraft®
• Emetostop®
• Medivert®
• Sea-Legs®
• Agyrax®

[edit] External links

• [1] – University of Berlin's Institute of Biochemistry
• [2] – Numark Pharmacies Information Page on Meclizine
• [3] Rxlist Medical Dictionary

v • d • e Antihistamines (primarily R06)
Aminoalkyl ethers	Bromazine, Carbinoxamine, Clemastine, Chlorphenoxamine, Diphenylpyraline, Diphenhydramine, Doxylamine
Substituted alkylamines	Brompheniramine, Chlorphenamine, Dexbrompheniramine , Dexchlorpheniramine, Dimetindene, Pheniramine, Talastine
Substituted ethylene diamines	Chloropyramine, Histapyrrodine, Mepyramine, Methapyrilene,Pyribenzamine
Phenothiazine derivatives	Alimemazine, Hydroxyethylpromethazine, Isothipendyl, Mequitazine, Methdilazine, Oxomemazine, Promethazine
Piperazine derivatives	Buclizine, Cetirizine, Chlorcyclizine, Cinnarizine, Cyclizine, Hydroxyzine, Levocetirizine, Meclozine, Niaprazine, Oxatomide
Others for systemic use	Acrivastine, Antazoline, Astemizole, Azatadine, Azelastine, Bamipine, Cyproheptadine, Deptropine, Desloratadine, Ebastine, Epinastine, Ketotifen, Loratadine, Mebhydrolin, Mizolastine, Phenindamine, Pimethixene, Pyrrobutamine, Rupatadine, Terfenadine, Triprolidine
For topical use	Bamipine, Chloropyramine, Chlorphenoxamine, Clemastine, Dimetindene, Diphenhydramine, Isothipendyl, Mepyramine, Promethazine, Thenalidine
Antiallergic agents excluding corticosteroids	Antazoline, Azelastine, Fexofenadine
Other antiallergics	Emedastine, Epinastine, Ketotifen, Olopatadine

meclizina is also found in the commercial name formula of:Bonadoxina made by pfizer;also combined with piridoxina.(for nausea&vomiting). (lily galvan u.s.a)