Mast cell stabilizer

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Mast cell stabilizers are cromone medications used to prevent or control certain allergic disorders. They block a calcium channel essential for mast cell degranulation, stabilizing the cell and so prevent the release of histamine[1] and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate.

As inhalers thay are used to treat asthma, as nasal sprays to treat Hay fever (allergic rhinitis) and as eye drops for allergic conjunctivitis. Finally in oral form they are used to treat the rare condition of mastocytosis.

[edit] References

  1. ^ http://www.mayoclinic.com/health/allergy-medications/AA00037
v • d • e
Medications commonly used in asthma and COPD (primarily R03)
Anticholinergics Ipratropium, Tiotropium
Short acting β2-agonists Salbutamol, Terbutaline
Long acting β2-agonists (LABA) Bambuterol, Clenbuterol, Fenoterol, Formoterol, Salmeterol
Corticosteroids Beclometasone, Budesonide, Ciclesonide, Fluticasone
Leukotriene antagonists Montelukast, Pranlukast, Zafirlukast
Xanthines Aminophylline, Theobromine, Theophylline
Mast cell stabilizers Cromoglicate, Nedocromil
Combination products Budesonide/formoterol, Fluticasone/salmeterol, Ipratropium/salbutamol
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