Manchester Centre for Integrative Systems Biology

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Manchester Centre for Integrative Systems Biology


Established	2005
Director	Professor Douglas B. Kell
Location	Manchester, United Kingdom
Campus	University of Manchester campus
Website	http://www.mcisb.org

The Manchester Centre for Integrative Systems Biology (MCISB) at the University of Manchester has been awarded £6.4M by the BBSRC and EPSRC to pioneer the development of new experimental and computational technologies in Systems Biology, and their exploitation. It is one of six BBSRC Integrative Systems Biology Research Centres in the UK. Through its Doctoral Training Centre, it is also involved in teaching the theoretical and practical aspects of systems biology.

The MCISB is based on the second floor of the Manchester Interdisciplinary Biocentre (MIB).

1 Areas of research
2 Members
3 References
4 See also
5 External links

[edit] Areas of research

The MCISB aims in pioneering the development of new experimental and computational technologies in Systems Biology and aiding in their exploitation. Systems Biology, being a rather new field, is developing and expanding rapidly. The common denominator of the research carried out in this field is that it co-evolves mathematical and experimental descriptions of interacting parts of organisms, e.g. global datasets of variables such as transcripts, proteins or metabolites, and seeks to integrate these different levels of information. The MCISB is intended to provide a hub for cutting-edge Systems Biology research, acting as a focal point for the creation of the necessary ideas and infrastructure, and establishing new methods and routines.

In the research to be carried out at the MCISB, the baker's yeast (Saccharomyces cerevisiae) will initially be used as a model organism, because it is highly amenable to genetic manipulations and to high-throughput technologies, thus offering an excellent starting position for demonstrating the principles and methods of Systems Biology.

A key focus of the MCISB is the development and application of high-throughput methods for the quantitative measurement of kinetic and binding constants on a genome wide scale. A second challenge is the mining (both text mining and database mining) of existing sources of information, and integrate these with the experimental data generated within the MCISB. The resulting dataset will be used to construct predictive mathematical models of metabolic pathways, employing both forward kinetic modelling (systems of ODEs) and inverse modelling. This should lead to computer models of (parts of) living cells. Some models are already available for in silico experimentation, others will be developed witin the centre.

[edit] Members

The atrium of the MIB, where the MCISB is based.

The MCISB consists of a Management Team of seven Principal Investigators that steers the Centre, and an interdisciplinary team employed as Experimental Officers of the Centre.

[edit] Principal Investigators (Management Team)

Prof Douglas Kell (EPSRC/RSC Research Chair in Bioanalytical Science; Director, MCISB)
Prof David Broomhead (Chair in Applied Mathematics; Director, Turing Institute)
Prof Simon Gaskell (Professor of Mass Spectrometry; Director, Michael Barber Centre for Mass Spectrometry)
Prof John McCarthy (Professor of Chemical Biology; Director, Manchester Interdisciplinary Biocentre)
Prof Steve Oliver (Professor of Genomics; Director, Centre for the Analysis of Biological Complexity)
Prof Norman Paton (Chair in Computer Science; co-Director, Information Management Group)
Prof Hans Westerhoff (AstraZeneca Professor of Systems Biology, School of Chemical Engineering and Analytical Science)