Macrophage Inflammatory Protein
From Wikipedia, the free encyclopedia
chemokine (C-C motif) ligand 3
|
|
Identifiers | |
Symbol | CCL3 SCYA3, MIP-1α |
HUGO | 10627 |
Entrez | 6348 |
OMIM | 182283 |
RefSeq | NM_002983 |
UniProt | P10147 |
PDB | 1B50 |
Other data | |
Locus | Chr. 17 q12 |
chemokine (C-C motif) ligand 4
|
|
Identifiers | |
Symbol | CCL4 SCYA4, MIP-1β, LAG1 |
HUGO | 10630 |
Entrez | 6351 |
OMIM | 182284 |
RefSeq | NM_002984 |
UniProt | P13236 |
PDB | 1HUM |
Other data | |
Locus | Chr. 17 q21-q23 |
Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1α and MIP-1β that are now officially named CCL3 and CCL4 respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins.[1] They activate human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 (IL-1), IL-6 and TNF-α from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17.[2]
[edit] References
- ^ Sherry et al. Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1-beta. J. Exp. Med. 168: 2251-2259, 1988.
- ^ Irving et al. Two inflammatory mediator cytokine genes are closely linked and variably amplified on chromosome 17q. Nucleic Acids Res. 18: 3261-3270, 1990.
[edit] See also
CCL1 - CCL2 - CCL3 - CCL4 - CCL5 - CCL6 - CCL7 - CCL8 - CCL9 - CCL10 - CCL11 - CCL12 - CCL13 - CCL14 - CCL15 - CCL16 - CCL17 - CCL18 - CCL19 - CCL20 - CCL21 - CCL22 - CCL23 - CCL24 - CCL25 - CCL26 - CCL27 - CCL28
CXCL1 - CXCL2 - CXCL3 - CXCL4 - CXCL5 - CXCL6 - CXCL7 - CXCL8 - CXCL9 - CXCL10 - CXCL11 - CXCL12 - CXCL13 - CXCL14 - CXCL15 - CXCL16 - CXCL17