Louise Jefferson

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Actress Isabel Sanford as Louise "Weezie" Jefferson, giving expression to her skepticism in a typical scene from the iconic American television program The Jeffersons.

Louise Jefferson (née Mills), played by Emmy-winning actress Isabel Sanford, is a fictional character who appeared first on the television series All in the Family and then became a main character on its spinoff, The Jeffersons. Her role lasted from 1971 to 1985, for 14 Years when The Jeffersons ended its run. She was often referred to as "Weezie" by her on-screen husband, George Jefferson. She was first introduced on All in the Family as a neighbor of Archie Bunker.

Louise was similar in many respects to the character Edith Bunker in All in the Family. Both were kind-hearted and had hot-headed husbands, and they were both good friends; however, Louise was not nearly as naïve as Edith. Prior to George Jefferson's first appearance on All in the Family, Louise had to contend with the arguments between Henry Jefferson, George's brother, and Archie Bunker.

In the first few seasons of The Jeffersons, Louise dealt with insulting remarks from Mother Jefferson, George's mother. She was a calming influence in the household compared to George's temper tantrums and over-inflated ego. She was friends with Tom Willis and Helen Willis, an interracial couple.

In the first episode of The Jeffersons, George insisted on hiring a maid. Both George and Louise grew up in poverty, and Louise felt it was not necessary to hire a maid. George won out and Florence Johnston (Marla Gibbs) was hired a few days a week. Over time, the role of Florence expanded and she became a live-in maid. Louise and Florence became great friends over the years while Florence and George often argued.