Lorcainide
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Lorcainide
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| Systematic (IUPAC) name | |
| N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-yl- 4-piperidyl)acetamide |
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| Identifiers | |
| CAS number | |
| ATC code | C01 |
| PubChem | |
| Chemical data | |
| Formula | C22H27ClN2O |
| Mol. mass | 370.915 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
Lorcainide is a class 1c antiarrhythmic agent. It was discovered at Janssen Pharmaceutica in 1968.
[edit] References
- Kesteloot H, Stroobandt R., Clinical experience with lorcainide (R 15 889), a new anti-arrhythmic drug, Arch Int Pharmacodyn Ther. 1977 Dec;230(2):225-34.
- Carmeliet E, Janssen PA, Marsboom R, Van Nueten JM, Xhonneux R., Antiarrhythmic, electrophysiologic and hemodynamic effects of lorcainide, Arch Int Pharmacodyn Ther. 1978 Jan;231(1):104-30.
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| class Ia | Ajmaline, Disopyramide, Prajmaline, Procainamide, Quinidine, Sparteine |
| class Ib | Aprindine, Lidocaine, Mexiletine, Tocainide |
| class Ic | Encainide, Flecainide, Lorcainide, Moricizine, Propafenone |
| class II | Propranolol, Metoprolol, Nadolol, Atenolol, Acebutolol, Pindolol see Beta blockers (C07) |
| class III | Amiodarone, Bretylium tosylate, Bunaftine, Dofetilide, Ibutilide, Sotalol |
| class IV | Verapamil, Diltiazem see Calcium channel blockers (C08) |
| class V | Adenosine, Atropine, Digoxin |
