Lofexidine
From Wikipedia, the free encyclopedia
 |
|
|
Lofexidine
|
|
| Systematic (IUPAC) name | |
| 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole | |
| Identifiers | |
| CAS number | ? |
| ATC code | N07 |
| PubChem | ? |
| Chemical data | |
| Formula | C11H12Cl2N2O |
| Mol. mass | 259.131 g/mol |
| Pharmacokinetic data | |
| Bioavailability | >90% |
| Protein binding | 80–90% |
| Metabolism | Hepatic glucuronidation |
| Half life | 11 hours |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | Oral |
Lofexidine is an alpha2-adrenergic receptor agonist, can be used as a short acting (short half life) anti-hypertensive, but mostly used to help with relief from symptoms of heroin or opiate withdrawal in opiate dependency. Used primarily in the United Kingdom [1]. See also clonidine.
| Antihypertensives (C02) and diuretics (C03) | |
|---|---|
| Antiadrenergic agents (including alpha) | Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine,Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine |
| Vasodilators | Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine |
| Other antihypertensives | Bosentan, Ketanserin |
| Low ceiling diuretics | Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine, Cicletanine |
| High ceiling diuretics | Bumetanide, Furosemide, Torasemide |
| Potassium-sparing diuretics | Amiloride, Eplerenone, Spironolactone, Triamterene |
