Livedoid vasculitis

From Wikipedia, the free encyclopedia

**Livedoid vasculitis**
*Classification & external resources*
ICD-10	L 95.0
ICD-9	xxx
DiseasesDB	7546
MedlinePlus	001478
eMedicine	derm/39

Livedoid vasculitis (also known as "livedo vasculitis", "livedo reticularis", and "livedoid vasculopathy") is a vascular disorder mostly affecting women. It may be aggravated by exposure to cold and occurs most often in the lower extremities. It can also be associated with the presence of anticardiolipin antibodies (the Antiphospholipid syndrome).

The condition's name derives from the Latin livere meaning bluish.

1 Aetiology
2 Treatment
3 Footnotes
4 External links

[edit] Aetiology

A number of conditions may cause the appearance of livedo reticularis:

Cutis marmorata telangiectatica congenita a rare congenital condition
Sneddon syndrome - association of Livedoid vasculitis and systemic vascular disorders, such as strokes, due to underlying genetic cause.^[1]
Idiopathic livedo reticularis - is the commonest cause of livedo reticularis appearance and is a completely benign condition of unknown cause affecting mostly young women during the winter.^[2] May be mild, but ulceration may occur later in the summer.^[3]
Secondary livedo reticularis:
- Vasculitis autoimmune conditions:
  - Livedoid vasculitis - with painful ulceration occurring in the lower legs
  - Polyarteritis nodosa
  - Systemic lupus erythematosus^[4]
  - Dermatomyositis
  - Rheumatoid arthritis
  - Lymphoma
  - Pancreatitis^[5]
  - Tuberculosis
  - Amantadine (drug)
- Obstruction of capillaries:
  - Cryoglobulinaemia - proteins in the blood that clump together in cold conditions.^[6]
  - Antiphospholipid syndrome due to small blood clots
  - Hypercalcaemia (raised blood calcium levels which may be deposited in the capillaries)
  - Haematological disorders of Polycythaemia rubra vera or Thrombocytosis (excessive red cells or platelets)
  - Infections (syphilis and tuberculosis)
  - Arteriosclerosis (cholesterol emboli)^[7]^[8] and homocystinuria (due to Chromosome 21 autosomal recessive Cystathionine beta synthase deficiency)
  - Intra-arterial injection (especially in drug addicts)

[edit] Treatment

Other than identifying and treating any underlying conditions in secondary livedo,^[9] idiopathic livedo reticularis itself may improve with warming the legs, but once established the skin discolouration may become permanent.

[edit] Footnotes

^ Sneddon I (Apr 1965). "Cerebro-Vascular Lesions And Livedo Reticularis". Br J Dermatol 77: 180-5. PMID 14278790.
^ Gibbs M, English J, Zirwas M (2005). "Livedo reticularis: an update". J Am Acad Dermatol 52 (6): 1009-19. PMID 15928620.
^ Feldaker M, Hines E, Kierland R (1955). "Livedo reticularis with summer ulcerations". AMA Arch Derm 72 (1): 31-42. PMID 14387292.
^ Golden R (Mar 1963). "Livedo reticularis in systemic lupus erythematosus". Arch Dermatol 87: 299-301. PMID 13948706.
^ Sigmund W, Shelley W (1954). "Cutaneous manifestations of acute pancreatitis, with special reference to livedo reticularis". N Engl J Med 251 (21): 851-3. PMID 13214346.
^ Langhof H, Braun G, Matzkowski H (1957). "[Livedo reticularis due to cold gelation of the blood by gamma-plasmacytoma.]". Arch Klin Exp Dermatol 205 (4): 343-50. PMID 13522017.
^ Kazmier F, Sheps S, Bernatz P, Sayre G (1966). "Livedo reticularis and digital infarcts: a syndrome due to cholesterol emboli arising from atheromatous abdominal aortic aneurysms". Vasc Dis 3 (1): 12-24. PMID 5903590.
^ Stewart W, Lauret P, Testart J, Thomine E, Boulliê M, Leroy D (1977). "[Cutaneous cholesterol emboli (author's transl)]". Ann Dermatol Venereol 104 (1): 5-8. PMID 843026.
^ Fleischer A, Resnick S (1990). "Livedo reticularis". Dermatol Clin 8 (2): 347-54. PMID 2191805.