LFA-1
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LFA-1 stands for Lymphocyte function-associated antigen-1.
LFA-1 is found on all T-cells and also on macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule, it is the first to bind T-cells to antigen-presenting cells and initially binds weakly. A signal from the T-cell receptor changes the conformation and prolongs the cell contact, allowing the T-cell to proliferate.
LFA-1 is part of the family of leukocyte integrins which are recognised by their common β-chains (CD18). LFA-1 also has a distinct α-chain (CD11a).
[edit] See also
[edit] Further reading
- Janeway, Travers, Walport, Shlomchik, Immunobiology 6th ed. (2005) Garland Science:NY
[edit] External links
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Antigen receptor (B-cell receptor, T cell receptor) - Complement - Fc (FcεRI, FcεRII, FcγRI, FcγRII, FcγRIII, FcαRI, Fcα/μR, Neonatal) - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like receptor - Lymphocyte homing receptor (CD44, L-selectin, Integrin alpha4beta1, LFA-1) - Pattern recognition/Toll-like (TLR 2, TLR 3) - Scavenger
Cytokine receptors: Type I (IL-2, IL-3) - Type II - Glycoprotein 130 - Chemokine receptor - TGF-beta receptors
