Levorphanol
From Wikipedia, the free encyclopedia
Levorphanol
|
|
Systematic (IUPAC) name | |
17-methylmorphinan-3-ol | |
Identifiers | |
CAS number | |
ATC code | ? |
PubChem | |
DrugBank | |
Chemical data | |
Formula | C17H23NO |
Mol. mass | 257.371 g/mol |
SMILES | search in | ,
Physical data | |
Melt. point | 23 °C (73 °F) |
Pharmacokinetic data | |
Bioavailability | ? |
Protein binding | 40% |
Metabolism | ? |
Half life | 11-16 hours |
Excretion | ? |
Therapeutic considerations | |
Pregnancy cat. |
C(US) |
Legal status | |
Routes | oral, intravenous, intramuscular, subcutaneous |
Levorphanol (Dromoran) is an opioid medication used to treat severe pain. The medication has a known abuse potential. In addition to acting on opioid receptors, its dextrorotory isomer, dextromethorphan, acts as an NMDA receptor antagonist.1 Typical doses include 2 mg by mouth or subcutaneous injection every 6 to 8 hours.
Levorphanol has affinity to μ, κ, and δ opioid receptors and has lack of complete cross-tolerance with morphine.
It is chemically related to dextromethorphan, an antitussive which is not an analgesic. Dextromethorphan is a salt of the methyl ether dextrorotatory isomer of levorphanol.
[edit] References
1. Brookoff D. Hospital Practice. 2000;35:45-59.