Talk:Leukotriene
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if an asthma patient had asprin did that risk his life ?
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[edit] Are there any natural/herbal products to block leukotrienes?
--Dcraw999 21:42, 29 July 2006 (UTC)
There are reports that antioxidants do:
- Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM. (1995 Mar 31). "The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease.". Clin Chim Acta. 235 (2): 207-19. PMID 7554275. Retrieved on 2007-01-10.
Obviously, if you're wanting to control the excessive leukotrienes in anaphylactic shock, you'll want something stronger. :-)
Omega-3 fatty acids, particularly EPA (found in fish oil) will not block leukotrienes, but they will cause the body to make less reactive ones.
David.Throop 17:09, 15 January 2007 (UTC)
- What is a "less reactive" LT?
- I'm sorry; I misspoke. The series 5 leukotrienes will induce much less inflammation than the series 4. They don't react. David.Throop 07:16, 11 February 2007 (UTC)
[edit] Nomenclature and series
The article states that Lks are derived from Arachidonic Acid. Actually, the series-4 LTs are - LTA4, LTB4. There are also the the series-5 LT, derived from EPA. But it is true that most of the LTs in the body are series 4 and derive from AA. So here's what I'm confused about. The series-4 LTs have 4 double bonds (that's where the '4' comes from.) The class is called 'triene' for three double bonds. Is the class misnamed? I don't think there even is a series-3 LT; unlike the case with other eicosanoids, DGLA doesn't have a double bond where it would need to in order for the lipoxygenase to react it. David.Throop 06:33, 4 January 2007 (UTC)
- I answered my own question by looking at [1]. The 'triene' indicates three conjugated double bonds. The LT derived from AA have four double bonds, but only three of them are conjugated. 20:09, 4 January 2007 (UTC)
Yes, there does exist LTA3 (and the other 3-series LTs, including LTB3).
- Really? Derived from DGLA? I googled for quite a while looking for it. Got a cite? David.Throop 07:16, 11 February 2007 (UTC)
Here are some references: Jakschik, B.A., Morrison, A.R., Sprecher, H. Products derived from 5,8,11-eicosatrienoic acid by the 5-lipoxygenase-leukotriene pathway. J Biol Chem 258 12797-12800 (1983).
Reddy C C; Bertler C; Hammarstrom S Conversion of dihomo-gamma-linolenic acid to mono- and dihydroxy acids by potato lipoxygenase: evidence for the formation of 8,9-leukotriene A3. Archives of biochemistry and biophysics (1990), 279(2), 211-7
Autoradiographic studies with fatty acids and some other lipids: a review. Becker W; Bruce A Progress in lipid research (1985), 24(4), 325-46 There are more that refer to natural LT-3s and there are also many references on the synthesis of LT-3s and LT-2s.
Also, don't forget the positional isomers, the 14,15-LTs. Here are some references: R.W. Bryant et al. J. Biol. Chem. 1995 260 3548 D.E. Sok et al. Biochem. Biophys. Res. Commun. 1982 104 1363—The preceding unsigned comment was added by GregKeyes (talk • contribs).
[edit] Images of the leukotriene molecules
It would be nice to include images of leukotriene molecules as has been done for prostaglandins and prostacyclins.Johner 22:34, 27 January 2007 (UTC)
The image of LTB4 is wrong. What is depicted is in fact 6-trans-LTB4, an isomer of the natural product. LTB4 should have a 6-Z bond. Also, the "lower chain" olefin, at C-14-15, is incorrect. It too should be cis.
- I checked it at PubChem and you're right. I've put in a request to have the image corrected. David.Throop 07:11, 11 February 2007 (UTC)
[edit] Prostaglandin antagonist
I'll more-or-less repeat what I posted over at Talk:Prostaglandin#Prostaglandin_antagonist. The material that was excised from this article is more general than just Prostaglandin antagonists. Zileuton isn't an antagonist. David.Throop 19:29, 28 February 2007 (UTC)
