Lefty (protein)

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left-right determination factor 1
Identifiers
Symbol LEFTY1 LEFTB
HUGO 6552
Entrez 10637
OMIM 603037
RefSeq NM_020997
UniProt O75610
Other data
Locus Chr. 1 q42.1
left-right determination factor 2
Identifiers
Symbol LEFTY2 TGFB4, EBAF
HUGO 3122
Entrez 7044
OMIM 601877
RefSeq NM_003240
UniProt O00292
Other data
Locus Chr. 1 q42.1
This article is about the protein Lefty. For other uses, see Lefty (disambiguation).

Lefty is a class of proteins that belongs to the TGF beta superfamily of proteins. It regulates TGFβ.

It is involved in embryogenesis and left-right patterning. There are many differences between the left and right sides, including heart and lung positioning. Mutations in these genes cause incorrect positioning of these organs.

There are two human subtypes: Lefty 1 and Lefty 2. Lefty2 may play a role in endometrial bleeding.

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TGF beta signaling pathway

TGF beta superfamily of ligands:

Activin A and B - Anti-müllerian hormone - Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) - Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, GDF9, GDF10, GDF11, GDF15) - Inhibin A and B - Myostatin - Nodal - TGF beta family (TGF-β1, TGF-β2, TGF-β3)

Type II receptors:ACVR2A - ACVR2B - AMHR2 - BMPR2 - TGFBR2 - TGFBR3

Type I receptors: ACVR1A - ACVR1B - ACVR1C - ACVRL1 - BMPR1A - BMPR1B - TGFBR1

Signal transducers/SMAD: R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4

Ligand Inhibitors: Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1

Coreceptors:BAMBI - Cripto Other: SARA

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