L-selectin

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selectin L (lymphocyte adhesion molecule 1)
Identifiers
Symbol	SELL LYAM1, LNHR
HUGO	10720
Entrez	6402
OMIM	153240
RefSeq	NM_000655
UniProt	P14151
Other data
Locus	Chr. 1 q23-q25

L-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognise sialylated carbohydrate groups. It is cleaved by ADAM17.

Contents 1 Ligands 2 Function 3 External links 4 References

[edit] Ligands

• GlyCAM-1, found in the high endothelial venules of the lymph nodes.
• CD34, found on endothelial cells.
• MadCAM-1, found on endothelial cells of gut associated lymphoid tissue.
• PSGL-1, binds with low affinity.

[edit] Function

L-selectin acts as a "homing receptor" for leukocytes to enter tissues at the site of inflammation. Ligands present on endothelial cells will bind to leukocytes expressing L-selectin, causing them to become localised at that point^[1].

[edit] External links

• MeSH L-Selectin
• Immunology at MCG 1/physresp

[edit] References