Ki-67 antigen
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Ki-67 is a nuclear antigen; it is now known to be expressed in all stages of the cell cycle except for G0 (the resting phase). Therefore, Ki-67 levels can be used to define areas of cell proliferation. The Ki-67 antigen is now used through the method of immunocytochemistry to aid in the grading classification of neoplasms such as astrocytomas. It is a large protein of approximately 395Da, encoded for by roughly 30,000bp within the human genome. Ki-67 is known to share structural similarities (it possesses a Fork-Head Associated domain FHA) with proteins that are involved in the regulation of the cell-cycle.
