Ketanserin

Ketanserin
Chemical name	-
Chemical formula	C₂₂H₂₂FN₃O₃
Molecular mass	395.43 g/mol
CAS number	74050-98-9
SMILES	O=C(C4=CC=C(F)C=C4)C(CC3)CCN3 CCN(C2=O)C(NC1=C2C=CC=C1)=O

Ketanserin is a serotonin receptor antagonist. It has the highest affinity for the serotonin 5-HT_2A receptor, but also binds less potently to the 5-HT_2C, 5-HT_2B, 5-HT_1D, alpha-adrenergic, and dopamine receptors. With tritium radioactively labeled ketanserin is used as a radioligand for the serotonin 5-HT_2A receptor, e.g. in receptor binding assays. Ketanserin was discovered at Janssen Pharmaceutica in 1980.

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v • d • e Antihypertensives (C02) and diuretics (C03)
Antiadrenergic agents (including alpha)	Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine,Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine
Vasodilators	Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine
Other antihypertensives	Bosentan, Ketanserin
Low ceiling diuretics	Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine, Cicletanine
High ceiling diuretics	Bumetanide, Furosemide, Torasemide
Potassium-sparing diuretics	Amiloride, Eplerenone, Spironolactone, Triamterene

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