Keratinocyte Growth Factor

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The Keratinocyte Growth Factor (KGF) is a growth factor present in the epithelialization-phase of wound healing. In this phase, keratinocytes are covering the wound, forming the epithelium.

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KGF, also refered to as FGF7 is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b). For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin.

There are 23 known FGFs, and 4 FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.

http://www-personal.umich.edu/~lpt/fgf/1fq9_files/side.jpg http://www-personal.umich.edu/~lpt/fgf/1fq9.htm

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