Karyolysis

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A feature of cells undergoing necrosis, or cell death caused by irreversible cell damage. The sequential descriptive order of events: Pyknosis, Karyorrhexis, Karyolysis.

Pyknosis: CONDENSATION of nuclear chromatin. Basophilia increases, cell shrinks.

Karyorrhexis: FRAGMENTATION of nuclear chromatin.

Karyolysis: LYSIS via DNAase activity. Basophilia decreases.


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