Karyolysis
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A feature of cells undergoing necrosis, or cell death caused by irreversible cell damage. The sequential descriptive order of events: Pyknosis, Karyorrhexis, Karyolysis.
Pyknosis: CONDENSATION of nuclear chromatin. Basophilia increases, cell shrinks.
Karyorrhexis: FRAGMENTATION of nuclear chromatin.
Karyolysis: LYSIS via DNAase activity. Basophilia decreases.