Kallikrein
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Kallikrein 1
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| Identifiers | |
| Symbol | KLK1 |
| HUGO | 6357 |
| Entrez | 3816 |
| OMIM | 147910 |
| RefSeq | NM_002257 |
| UniProt | P06870 |
| Other data | |
| EC number | 3.4.21.35 |
| Locus | Chr. 19 q13.3 |
Kallikreins (tissue and plasma kallikrein) are a subgroup of the serine protease family that liberate kinins (BK and KD) from the kininogens.[1]
Prekallikrein is the precursor of plasma kallikrein. It can only activate kinins after being activated itself by factor XII or other stimuli.
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[edit] Genes
There are 15 known kallikreins: KLK1, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK12, KLK13, KLK14, KLK15
[edit] Clinical significance
Kallikreins are targets of active investigation by drug researchers as possible biomarkers for cancer.[2][3]
Prostate-specific antigen (PSA; hk3, human kallikrein gene 3) and human glandular kallikrein (hK2) are used as tumor markers for prostate cancer.
[edit] See also
[edit] External links
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This biochemistry article is a stub. You can help Wikipedia by expanding it. |
Trypsin - Chymotrypsin - Elastase (Neutrophil, Pancreatic) - Enteropeptidase
Acrosin - Pronase - Proprotein convertases (1, 2) - Subtilisin/Furin
Immune (Chymase, Granzyme, Tryptase, Proteinase 3/Myeloblastin) - Venombin (Ancrod, Batroxobin)
Complement system: Factor B - Factor D - Factor I - MASP (MASP1, MASP2)
Coagulation factors: Thrombin - Factor VIIa - Factor IXa - Factor Xa - Factor XIa - Factor XIIa - Kallikrein (PSA) - Fibrinolysis: Plasmin - Tissue plasminogen activator - Urinary plasminogen activator
