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In the kidney, the juxtaglomerular cells (JG cells) are cells that synthesize, store, and secrete the enzyme renin. They are specialized smooth muscle cells in the wall of the afferent arteriole that delivers blood to the glomerulus. In synthesizing renin, they play a critical role in the renin-angiotensin system and thus in renal autoregulation, the self-governance of the kidney.
In appropriately stained slides, juxtaglomerular cells are distinguished by their granulated cytoplasm.
[edit] External links
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Urinary system - Kidney |
| Renal fascia, Renal capsule, Renal cortex (Renal column), Renal medulla (Renal sinus, Renal pyramids), Renal lobe, Cortical lobule, Medullary ray, Nephron
afferent circulation: Renal artery → Interlobar arteries → Arcuate arteries → Cortical radial arteries → Afferent arterioles → Renal corpuscle (Glomerulus, Bowman's capsule)
kidney tubule: Proximal tubule → Loop of Henle (Descending, Thin ascending, Thick ascending) → Distal convoluted tubule → Connecting tubule → Collecting ducts → Duct of Bellini → Renal papilla → Minor calyx → Major calyx → Renal pelvis → Ureter
efferent circulation: Glomerulus → Efferent arterioles → Peritubular capillaries/Vasa recta → Arcuate vein→ Interlobar veins→ Renal vein
juxtaglomerular apparatus: Macula densa, Juxtaglomerular cells, Extraglomerular mesangial cells
filtration: Glomerular basement membrane - Podocyte - Filtration slits - Intraglomerular mesangial cells
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