Julio Gutierrez

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Julio Anacleto Gutierrez is a Mexican-American scientist. In the summer of 2000, Julio accepted a postion at Mount Sinai Hospitial in New York City, where he works with Dr. Andrea Branch studying the hepatitis C virus (HCV). The main focus of their research was to identify the natural history of the novel HCV protein, the Alternate Reading Frame Protein. Additionally, his reseasrch has identified ascitic fluid from HCV patients as a rich source of anti-HCV antibodies, and has been successful in purifying antibodies to regions of the HCV genome that had never been available.

Publications

1. Branch,A.D., Stump,D.D., Gutierrez,J.A., Eng,F., and Walewski,J.L. 2005. The hepatitis C virus alternate reading frame (ARF) and its family of novel products: The alternate reading frame protein/F-protein, the double-frameshift protein, and others. Seminars in Liver Disease 25:105-117. 2. Lawal,A., Basler,C., Branch,A., Gutierrez,J., Schwartz,M., and Schiano,T.D. 2004. Influenza vaccination in orthotopic liver transplant recipients: Absence of post administration ALT elevation. American Journal of Transplantation 4:1805-1809. 3. Schiano,T.D., Gutierrez,J.A., Walewski,J.L., Fiel,M.I., Cheng,B., Bodenheimer,H., Jr., Thung,S.N., Chung,R.T., Schwartz,M.E., Bodian,C. et al. 2005. Accelerated hepatitis C virus kinetics but similar survival rates in recipients of liver grafts from living versus deceased donors. Hepatology 42:1420-1428. 4. Stanca,C.M., Bach,N., Krause,C., Tandon,N., Freni,M.A., Gutierrez,J.A., Bodian,C., Lopez,J., Berk,P.D., Bodenheimer,H.C. et al. 2005. Evaluation of fatigue in US patients with primary biliary cirrhosis. American Journal of Gastroenterology 100:1104-1109. 5. Walewski,J.L., Gutierrez,J.A., Branch-Elliman,W., Stump,D.D., Keller,T.R., Rodriguez,A., Benson,G., and Branch,A.D. 2002. Mutation Master: Profiles of substitutions in hepatitis C virus RNA of the core, alternate reading frame, and NS2 coding regions. Rna-A Publication of the Rna Society 8:557-571. 6. Gutierrez J.A., Klepper A., Walewski J.L., Khaitova V., Jefferson D.M., Schiano T.D., Branch A.D. 2006. Ascites in HCV: A Previously Untapped Source of Antibodies. To be Submitted to Hepatology. 7. Hytiroglou P., Gutierrez J.A., Freni M., Odin JA, Stanca C.M., Merati S., Schiano T.D., Branch A.D., Thung S.N. 2006. Recurrence of Primary Biliary Cirrhosis (PBC) and De Novo Autoimmune Hepatitis after Orthotopic Liver Transplantation for PBC: A “Blinded” Histologic Study. Manuscript in preparation.

Abstracts

1. Ala,A., Ahmado,I., Stanca,C., Tandon,N., Schiano,T., Branch,A., Gutierez,J., Odin,J., and Bach,N. 2004. The prevalence of primary biliary cirrhosis is increased near toxic waste sites in New York City. Hepatology 40:205A. 2. Blank,A., Schiano,T., Gutierrez,J.A., Gan,D., Thung,S.N., and Fiel,M.I. 2004. The influence of donor age, gender mismatch and harvesting injury on fibrosis progression rate in recurrent hepatitis C (HCV) post-liver transplantation. Hepatology 40:243A. 3. Branch,A.D., Walewski,J.L., Gutierrez,J.A., Fernandez,E.J., Im,G.Y., Dieterich,D.T., Schiano,T.D., Sigal,S.H., Schilsky,M.L., Schwartz,M.E. et al. 2003. HCV alternate reading frame proteins (ARFPs) may be virulence factors that help the virus survive adverse conditions. Hepatology 38:468A-469A. 4. Fiel,M.I., Desman,D., Schiano,T.D., Gutierrez,J.A., Lento,P., Emanuel,P.O., and Thung,S.N. 2005. Prevalence of steatohepatitis and its association with splenomegaly and abdominal subcutaneous adipose thickness: An autopsy study. Modern Pathology 18:6A-7A. 5. Fiel,M.I., Desman,G., Schiano,T.D., Gutierrez,J.A., Lento,P., Emmanuel,P.O., and Thung,S.N. 2005. Prevalence of steatohepatitis and its association with splenomegaly and abdominal subcutaneous adipose thickness: An autopsy study. Laboratory Investigation 85:6A-7A. 6. Gutierrez,J., Walewski,J.L., Fernandez,E.J., Dieterich,D., Schiano,T.D., Roayaie,S., Thung,S.N., Fiel,M.I., Schwartz,M.E., and Branch,A.D. 2003. High Incidence of Antibodies to the Alternate Reading Frame Protein in Patients with Hepatitis C and Hepatocellular Carcinoma. Mount Sinai School of Medicine Medical Student Abstracts 25. 7. Gutierrez,J.A., Walewski,J.L., Fernandez,E.J., Dieterich,D., Schiano,T.D., Roayaie,S., Thung,S.N., Fiel,M.I., Schwartz,M.E., and Branch,A.D. 2005. Antibodies to the Alternate Reading Frame Protein in Hepatitis C with Hepatocellular Carcinoma. Bristol Meyers Squibb National Medical Fellowship. 8. Gutierrez,J.A., Branch,A.D., Amato,N., Bodian,C., and Bach,N. 2002. Bone mineral density in the lumbar spine is lower in women with primary biliary cirrhosis than in an age-matched group of other women. Hepatology 36:498A. 9. Gutierrez J.A., Klepper A., Walewski J.L., Khaitova V., Jefferson D.M., Schiano T.D., Branch A.D. 2006. Ascites in HCV: A Previously Untapped Source of Antibodies. Hepatology (accepted abstract and poster). 10. Hytiroglou,P., Merati,S., Gutierrez,J.A., Lopez,J.V., Bodenheimer,H., Bach,N., Kim,L., Schiano,T.D., Branch,A.D., Thung,S. et al. 2002. "Blinded" histologic analysis of liver biopsy specimens from women with primary biliary cirrhosis following orthotopic liver transplantation. Hepatology 36:498A. 11. Kedia,S., Bach,N., Gutierrez,J.A., Holender,T., Sellner,H.A., and Schilsky,M.L. 2002. Reproductive health of patients with Wilson's disease and other chronic liver diseases. Hepatology 36:336A. 12. Lawal,A., Basler,C., Branch,A., Gutierrez,J., Schwartz,M., and Schiano,T. 2004. Influenza vaccination in orthotopic liver transplant recipients: Efficacy and absence of ALT elevation. Gastroenterology 126:A664-A665. 13. Schiano,T.D., Gutierrez,J.A., Walewski,J.L., Fiel,M.I., Cheng,B., Nelson,C., Bodenheimer,H., Thung,S.N., Chung,R., Schwartz,M.E. et al. 2004. HCV RNA, core antigen, ALT values, and histology after liver transplantation: Two year follow-up of CDLT versus LDLT. Hepatology 40:164A. 14. Schwartz,M., Walewski,J.L., Roayaie,S., Gutierrez,J.A., Fernandez,E.J., Dieterich,D., Schiano,T., Thung,S.N., Fiel,M.I., and Branch,A.D. 2004. The novel hepatitis C virus (HCV) alternate reading frame proteins (ARFPs) are over-expressed in patients with HCV cirrhosis and hepatocellular carcinoma (HCC). Annals of Surgical Oncology 11:S50.

   15.     Stanca,C., Bach,N., Gutierrez,J., Tandon,N., Bodian,C., Jaffe,D., Bodenheimer,H.C., Branch,A.D., and Odin,J.A. 2002. Comparison of outcome measures used in primary billary cirrhosis clinical studies. Hepatology 36:421A.

16. Tandon,N., Gutierrez,J., Stanca,C., Fernandez,J., Merati,S., Lopez,J., Jaffe,D., Leonard,J., Thung,S.N., Berk,P. et al. 2002. Artzt PBC database: Design, implementation and validation. Hepatology 36:500A. 17. Uriel,A.J., Gutierrez,J.A., Reichenberg,A., and Dieterich,D.T. 2003. Increase in CD4 lymphocyte count following hepatitis C viral clearance in a cohort of HIV/HCV infected individuals. Hepatology 38:630A. 18. Walewski,J.L., Keller,T.R., Stump,D.D., Gutierrez,J.A., Branch-Elliman,W., Rodriguez,A., Benson,G., and Branch,A.D. 2001. A target domain in the newly-discovered HCV alternate reading frame protein identified with a novel sequence analysis package. Hepatology 34:445A. 19. Walewski J.L., Gutierrez J.A., Klepper A., Branch A.D. 2006. Increased Anti-ARFP Antibody Positivity is Associated with End-Stage Liver Disease. Hepatology (accepted abstract and poster).