Talk:Itraconazole

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[edit] Scary wrong

Whoever wrote that neurologists use itraconazole for CNS infections, good luck. The drug doesn't enter CNS. - Emt147 ^Burninate! 01:07, 27 December 2006 (UTC)

[edit] Itraconazole HAS been prescribed for fungal meningitis

Actually, as I wrote, it has been prescribed for fungal meningitis, specifically meningitis caused by the spores of valley which are inhaled, causing pneumonia and then moves to infect the meninges, which is called fungal meningitis.

Here is my source which you can access; can you provide your source which I can access electronically?

"Itraconazole was reported to be potentially efficacious for coccidioidal meningitis" Citation: Tucker RM, Denning DW, Dupont B, Stevens DA. Itraconazole therapy for chronic coccidioidal meningitis. Ann Intern Med 1990; 112:108–12.

It has also been used in cats and dogs: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B75BB-4HDNVHP-5&_user=4421&_coverDate=11%2F30%2F2005&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000059598&_version=1&_urlVersion=0&_userid=4421&md5=8d6f9031c7864edee2844bdcddb74a01#SECX8

128.120.57.223 23:49, 15 February 2007 (UTC)

My source is the Sanford Guide to Antimicrobial Therapy and clinical experience. You might be able to reach therapeutic CNS levels over time but certainly not in acute infections, and cocci meningitis is rather uncommon. To quote the Hopkins Antibiotic Guide (http://www.hopkins-abxguide.org), Negligible CSF penetration, however treatment has been successful for cryptococcal and coccidioidal meningitis. - Emt147 ^Burninate! 05:26, 16 February 2007 (UTC)

[edit] In conclusion, itraconazole HAS been prescribed as treatment for meningitis. I was not wrong.

71.137.214.216 14:42, 8 March 2007 (UTC)