Ipratropium

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Ipratropium
Systematic (IUPAC) name
[8-methyl-8-(1-methylethyl)- 8-azoniabicyclo[3.2.1] oct-3-yl] 3-hydroxy-2-phenyl-propanoate
Identifiers
CAS number	60205-81-4
ATC code	R01AX03 R03BB01
PubChem	43232
DrugBank	APRD00537
Chemical data
Formula	C20H30NO3
Mol. mass	332.457 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	0 to 9% in vitro
Metabolism	Hepatic
Half life	2 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	B(US)
Legal status	POM(UK)
Routes	inhalation

Ipratropium is an anticholinergic drug (trade name: Atrovent®) administered by inhalation for the treatment of obstructive lung diseases. It acts by blocking muscarinic receptors in the lung, inhibiting bronchoconstriction and mucus secretion. It is a non-selective muscarinic antagonist, and does not diffuse into the blood, which prevents systemic side effects.

Ipratropium is also combined with salbutamol (trade name: Combivent) for the management of COPD. Ipratropium is also combined with fenoterol (trade name: Duovent) for the management of asthma.

[edit] Sources

• Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
• Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4
• (http://www.boehringer-ingelheim.com)

[edit] External links

• Links to external chemical sources

v • d • e Medications commonly used in asthma and COPD (primarily R03)
Anticholinergics	Ipratropium, Tiotropium
Short acting β2-agonists	Salbutamol, Terbutaline
Long acting β2-agonists (LABA)	Bambuterol, Clenbuterol, Fenoterol, Formoterol, Salmeterol
Corticosteroids	Beclometasone, Budesonide, Ciclesonide, Fluticasone
Leukotriene antagonists	Montelukast, Pranlukast, Zafirlukast
Xanthines	Aminophylline, Theobromine, Theophylline
Mast cell stabilizers	Cromoglicate, Nedocromil
Combination products	Budesonide/formoterol, Fluticasone/salmeterol, Ipratropium/salbutamol