Talk:Integral membrane protein
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Article Grading: The following comments were left by the quality and importance raters: (edit ยท refresh) Changed rating to "high" as this is high school/SAT biology content. The article seems to overlap with transmembrane protein. - tameeria 22:42, 18 February 2007 (UTC) |
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"Cells assemble IMPs in the endoplasmic reticulum. A short signal sequence at the N-terminus typically marks a protein as destined for installation in the membrane." This is true only if the protein membrane insertion is processed during the protein translation. But there's a lot of protein where the membrane insertion mechanism is post-translational! Additionally, procaryotes have no endoplasmic reticulum but have membrane proteins!
[edit] Introduction
In addition to the fact, that integral membrane proteins are not generally cotranslationally inserted into the ER, i.e. membrane proteins in organells like mitochondira, chloroplast etc., membrane proteins are not generally ancored to the cytoskeleton. It might be true for many in the plasma membrane, but it is not at all a principal feature of membrane proteins.
The rest of the article is really good. It might be worth to mention beta-barrels, as structural feature of integral membrane molecule, and maybe also their function in bioenergetics, as all protein complexes of the oxidive phosphorylation chain in the mitochondria and in the photophosphorylation chain in the chloroplast consist of integral membrane proteins.
- Given that you obviously know about the subject, could you make edits as you see appropriate? You see, that is what being bold is all about. JFW | T@lk 00:29, 25 August 2005 (UTC)
[edit] Structure Section
I'm partally aggreed with the Structure section. In the case of protein, structure means alpha-halix, b-strand, etc. I think it is more correct to talk about protein-membrane interactions. In this case, there is 2 category of interaction : transmembrane or non-transmembrane. Thus the transmembrane category can be related to transmembrane helices and b-barrels while the non-transmembrane category can be related to in-plane membrane helices, lipid-linked proteins and other type of interactions such as the cardiotoxin one.
[edit] Further development
I think we should simply refer here to two other main articles: Transmembrane proteins and Integral monotopic proteins. This second article should be created. Biophys 01:50, 19 February 2007 (UTC)
