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Interstate 759 (abbreviated I-759) is the 3-digit spur of Interstate 59 that extends just south of downtown Gadsden in Etowah County, Alabama at a junction with U.S. Route 411. The route is just over four miles long. It opened between 1985 and 1989. Currently there are plans to extend the spur to U.S. Route 278 on the east side of Gadsden, and extending it towards Attalla and linking it to State Route 77 on the west.
East of U.S. 411, the route continues as State Route 759.