Interleukin 31
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Interleukin 31
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| Identifiers | |
| Symbol | IL31 |
| HUGO | 19372 |
| Entrez | 386653 |
| OMIM | 609509 |
| RefSeq | NM_001014336 |
| UniProt | Q6EBC2 |
| Other data | |
| Locus | Chr. 12 q24.31 |
Interleukin-31 (IL-31) is a cytokine with a four-helix bundle structure, which is preferentially produced by type 2 helper T cells (Th2). The structure of IL-31 places it in the IL-6 family of cytokines. IL-31 signals via a receptor complex that is composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor subunits. These receptor subunits are expressed in activated monocytes and in unstimulated epithelial cells. IL-31 is believed to play a role in inflammation of the skin.[1]
[edit] References
- ^ Stacey R Dillon et al., Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice., Nature Immunology, 2004, Volume 5, pages 752-760.
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