Interleukin
From Wikipedia, the free encyclopedia
Interleukins are a group of cytokines (secreted signaling molecules) that were first seen to be expressed by white blood cells (leukocytes, hence the -leukin) as a means of communication (inter-). The name is something of a relic though; it has since been found that interleukins are produced by a wide variety of bodily cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency.
A list of interleukins with function:
- IL-1: secreted by macrophages, induces acute phase reaction, fever.
- IL-2: secreted by T cells in an autocrine fashion, stimulates growth and differentiation of T cell response. Can be used in immunotherapy to treat cancer.
- IL-3: secreted by T cells, stimulates bone marrow stem cells.
- IL-4: involved in proliferation of B cells and the development of T cells and mast cells. Important role in allergic responses.
- IL-5: role in differentiation of B cells, eosinophil production, and IgA production
- IL-6: secreted by macrophages, induces acute phase reaction
- IL-7: involved in B, T, and NK cell survival, development, and homeostasis
- IL-8: Neutrophil chemotaxis
- IL-9: stimulates mast cells
- IL-10: inhibits Th1 cytokine production
- IL-11: acute phase protein production
- IL-12: NK cell stimulation, Th1 cells induction
- IL-13: Stimulates growth and differentiation of B-Cells, inhibits Th1 cells and the production of macrophage inflammatory cytokines
- IL-14:
- IL-15: Induces production of Natural Killer Cells
- IL-16:
- IL-17: Induces production of inflammatory cytokines
- IL-18: Induces production of Interferon-Gamma (IFNy)
- IL-19:
- IL-20:
- IL-21:
- IL-22:
- IL-23: Increases angiogenesis but reduces CD8 T-cell infiltration
- IL-24:
- IL-25:
- IL-26:
- IL-27:
- IL-28:
- IL-29:
- IL-30:
[edit] Links
- HGNC Gene Family Nomenclature: Interleukin and Interleukin Receptor Gene Symbols
- Interleukin Antibody Review
Autocrine motility factor - Chemokine - Hematopoietic (Stem cell factor, Colony-stimulating factor) - Hepatocyte growth factor - Interferon - Interleukin - Leukemia inhibitory factor - Lymphokine - Monokine - Oncostatin M - Osteopontin - TGF beta - Tumor necrosis factor