Inheritance of intelligence

From Wikipedia, the free encyclopedia

The subject of the inheritance of intelligence is the genetics of mental abilities. Research in this field is facing a number of difficulties, because intelligence as a trait is a fuzzy concept. The genetics of intelligence is thus operationally restricted to the genetics of IQ or the underlying g factor. Nevertheless, intelligence is embedded in the personality as a whole and its development during the lifespan of an individual. Not only is the number of social and biological factors influencing the development of a person a large one, but also there are a number of underlying genes with many minor and very few major effects.

Interindividual differences in the learning ability are also known from mice, dogs and other animals, and the achievements of pure strains can be improved by breeding. In such a way also behaviour genetics is contributing to our knowledge of the inheritance of mental traits. There is an open question to which degree differences of animal behaviour have any meaning for differences in human intelligence.

The main interest of the broader public is focused on the role played by nature versus nurture in the development of IQ. However, the science of genetics is trying to discover the genes contributing to IQ differences. The area, along with the entire field of intelligence research, has been strongly criticised by some academics and the media (see The Mismeasure of Man).

1 Methods and results
2 Literature
3 See also
4 External links

[edit] Methods and results

[edit] The similarity of relatives with respect to their intelligence

In the case of the inheritance of a certain level of IQ or a certain degree of giftedness, the relatives of probands with a high IQ exhibit a comparable high IQ with a much higher probability than the general population. In terms of correlation statistics, this means that theoretically the correlation of tests scores between monozygotic twins should be 1.00; practically the upper bound of this correlation is given by the reliability of the test.

Siblings and dizygotic twins share half of their genes and the correlation of their scores should be 0.50, half-siblings 0.25 and is halved by one additional decreasing degree of genetic relationship.

Bouchard and McGue (1981) have reviewed such correlations reported in 111 original studies. The mean correlation of IQ scores between monozygotic twins was 0.86, between siblings, 0.47, between half-siblings, 0.31, and between cousins, 0.15. From such data the heritability of IQ can be estimated, varying between 0.40 and 0.80.

In 1869, Francis Galton replaced mere speculations by statistical data through his book, Hereditary Genius:

Highly Gifted Men and the Percentage of their Highly Gifted Male Relatives

(classified by occupation and achievement)


	Galton	Terman	Brimhall	Weiss
	%	%	%	%	n (Weiss)
Probands	100	84⁺	100	97⁺	1972: 1329 1994: 357
Fathers	26	41	29	40	346
Brothers	47	-	49	49	220
Sons	60	64^*	-	55	77
Grandfathers	14	-	9	9	681
Uncles	16	-	13	14	615
Nephews	23	-	-	22	76
Grandchildren	14	-	-	-	-
Greatgrandfathers	0	-	-	4	1290
Uncles of the parents	5	-	-	5	1996
Cousins	16	-	9^#	18	570
Greatgrandchildren	7	-	-	-	-
Cousins of parents	-	-	-	11	2250
"+": classified by occupation; 100%, if classified by test "": classified only by IQ; classification by occupation gives about 55%; n = 820. "#": some cousins were still too young and did not have full opportunity to become distinguished "-": no data Sources:'''* Francis Galton: Hereditary Genius. London 1869.[1]. 100 famous Famous men (n = 43) of science and the percentage of their famous male relatives. M. H. Oden: The fulfillment of promise: 40-year follow-up of the Terman gifted group. Genetical Psychology Monographs 77 (1968) 3-93. The mean IQ (transformed to 100;15) of the sample of probands was 146 (n = 724); the cut-off score IQ 137. Dean R. Brimhall: Family resemblances among American men of science. The American Naturalist 56 (1922) 504-547; 57 (1923) 74-88, 137-152, and 326-344. In 1915 questionnaires were filled in by 956 distinguished American men of science and their relatives. Volkmar Weiss: Mathematical giftedness and family relationship. European Journal for High Ability 5 (1994) 58-67.[2] Highly gifted males (mean IQ 135 +/- 9) and their relatives in professions, typically associated with an IQ above 123.

Despite the differences in methods and societies, there is a notable parallelism in the published statistics. The ITO-method by Li and Sacks (1954) allows from this set of data the estimation of the underlying number of genes and their allele frequencies.

[edit] The inheritance of cognitive deficits

There is no doubt that genes are in many cases the cause of an IQ below 100. The number of such genes already known is in the hundreds. For example, a mutation of the gene GDI1[3] is associated with an IQ below 70. The public has free and open access to the current data in the field through the OMIM database.

There are number of known cases where the homozygotes have severe cognitive deficits and the heterozygotes show a small decrease of IQ. In such metabolic pathways further SNPs of such genes are investigated whether they are influencing IQ or not. For example, one SNP of the gene ALDH5A1[4] causes an IQ difference of around 1.5 points[5].

[edit] Development of IQ

It is reasonable to expect that genetic influences on traits like IQ should become less important as one gains experiences with age. Surprisingly, the opposite occurs. Heritability measured in infancy are as low as 20%, around 40% in middle childhood, and as high as 80% in adulthood. Plomin et al. (2001, 2003); although this could also suggest that genetic influences have an effect on a person's predisposition to learn and develop IQ.

[edit] Literature

P. McGuffin: The quantitative and molecular genetics of human intelligence. Novartis Found Symp. (2000) 243-255.
G. Meisenberg: Genes for intelligence. A review of recent progress. Mankind Quarterly 36 (Winter 2005) 139-164.
A. Payton: Investigating cognitive genetics and its implications for the treatment of cognitive deficit. Genes Brain Behav. 5 Suppl 1(2006) 44-53.