Indiana State Road 66

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State Road 66 in the U.S. State of Indiana is an east-west highway in the southernmost portion of the state. It begins at the eastern end of a toll bridge over the Wabash River in New Harmony and ends at U.S. Highway 150 east of Hardinsburg. SR 66 is a divided limited-access highway in the metropolitan Evansville area and also between the unincorporated communities of Yankeetown and Hatfield. For the most part, however, S.R. 66 is undivided rural highway, and a large portion of its route (from just east of Newburgh to SR 62 at Sulphur) carries the designation of the Ohio River Scenic Byway.

S.R. 66 passes through the following cities and towns, from west to east:

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