Indapamide

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Chemical structure of Indapamide
Indapamide
Systematic (IUPAC) name
4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)- 3-sulfamoyl-benzamide
Identifiers
CAS number 26807-65-8
ATC code C03BA11
PubChem 3702
DrugBank APRD01031
Chemical data
Formula C16H16ClN3O3S 
Mol. mass 365.835 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 71-79%
Metabolism Hepatic
Half life 14-18 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Oral

Indapamide is a thiazide diuretic drug, usually used in the treatment of hypertension and edema caused by congestive heart failure.

Indapamide is marketed as NATRILIX SR®

NATRILIX SR abridged prescribing information

Contents

[edit] Form and Composition:

Each sustained-release coated tablet contains 1.5 mg of 1-(4-chloro-3-sulfamyl-benzamido)-2-methylindoline (or indapamide hemihydrate).

[edit] Indication:

Essential hypertension.

[edit] Contraindications:

Hypersensitivity to sulfonamides, Severe renal failure, Hepatic encephalopathy or severe hepatic failure, Hypokalemia.

[edit] Combination treatments:

Natrilix SR may be combined with all nonthiazide antihypertensive agents, with ß-blockers, calcium channel blockers, and ACE inhibitors.

[edit] Drug combinations to be avoided:

Lithium, nonantiarrhythmic drugs causing wave burst arrhythmia (astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine).

[edit] Precautions:

Pregnancy. Lactation. Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout. Although no allergic manifestations have been reported during clinical trials, patients with a history of allergy to sulfonamide derivatives should be closely monitored.

[edit] Adverse effects:

Hypokalemia, Fatigue, Orthostatic hypotension, Allergic manifestations.

[edit] Dosage and administration:

One tablet daily.

[edit] Overdosage:

Symptoms of overdosage would be those associated with a diuretic effect: electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting the electrolyte abnormalities.


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