Ifosfamide

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Ifosfamide
Systematic (IUPAC) name
3-(2-chloroethyl)-2 -[(2-chloroethyl)amino]tetrahydro -2H-1,3,2-oxazaphosphorine 2-oxide
Identifiers
CAS number	3778-73-2
ATC code	L01AA06
PubChem	3690
DrugBank	APRD00007
Chemical data
Formula	C7H15Cl2N2O2P
Mol. mass	261.1
Pharmacokinetic data
Bioavailability	100%
Metabolism	Hepatic
Half life	60-80% in 72 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status	?
Routes	intravenously

Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is a white powder which, when prepared for use in chemotherapy becomes a clear, colorless fluid. The delivery is intravenous, and is given as a treatment for a variety of cancers, including:

• Testicular cancer
• Breast cancer
• Lymphoma (Non-Hodgkin)
• Soft tissue sarcoma
• Osteogenic sarcoma
• Lung cancer
• Cervical cancer
• Ovarian cancer
• Bone cancer

Ifosfamide is often used in conjunction with Mesna to avoid internal bleeding in the patient.

[edit] External links

• ACS Drug Guide: Ifosfamide
• Harvard Medical School Health Information on Ifosfamide
• MedlinePlus Drug Information
• BC Cancer Agency Ifosamide Information (Professional)
• RxList Online Drug Index Ifosamide Listing

v • d • e Chemotherapeutic agents/Antineoplastic agents (L01)
Alkylating agents	Nitrogen mustards: (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan). Nitrosoureas:(Carmustine, Fotemustine, Lomustine, Streptozocin). Platinum: (Carboplatin, Cisplatin, Oxaliplatin, BBR3464). Busulfan, Dacarbazine, Mechlorethamine, Procarbazine, Temozolomide, ThioTEPA, Uramustine
Antimetabolites	Folic acid: (Aminopterin, Methotrexate, Pemetrexed, Raltitrexed). Purine:(Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine). Pyrimidine:(Capecitabine, Cytarabine, Fluorouracil, Floxuridine, Gemcitabine)
Spindle poison plant alkaloids	Taxane: (Docetaxel, Paclitaxel). Vinca: (Vinblastine, Vincristine, Vindesine, Vinorelbine).
Cytotoxic/antitumor antibiotics	Anthracycline family: (Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mitoxantrone, Valrubicin). Bleomycin, Hydroxyurea, Mitomycin, Actinomycin
Topoisomerase inhibitors	Camptotheca: (Camptothecin, Topotecan, Irinotecan), Podophyllum:(Etoposide, Teniposide).
CI monoclonal antibodies	Alemtuzumab, Bevacizumab, Cetuximab, Gemtuzumab, Panitumumab, Rituximab, Tositumomab, Trastuzumab
Photosensitizers	Aminolevulinic acid, Methyl aminolevulinate, Porfimer sodium, Verteporfin
Kinase inhibitors	Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Nilotinib, Sorafenib, Sunitinib, Vandetanib (ZD6474)
Other	Alitretinoin, Altretamine, Amsacrine, Anagrelide, Arsenic trioxide, Asparaginase, Bexarotene, Bortezomib, Denileukin diftitox, Estramustine, Hydroxycarbamide, Masoprocol, Mitotane, Pegaspargase, Tretinoin