ICAM-1

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intercellular adhesion molecule 1 (CD54)
Identifiers
Symbol	ICAM1
HUGO	5344
Entrez	3383
OMIM	147840
RefSeq	NM_000201
UniProt	P05362
Other data
Locus	Chr. 19 p13.3-13.2

ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages and lymphocytes.

ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies.^[1] ^[2] While ICAM-1 has not been shown to be directly correlated with cerebral vasospasm, a secondary insult which affects 70% of SAH patients, treatment with anti-ICAM-1 reduced the severity of vasospasm.

[edit] References

^ Polin RS, Bavbek M, Shaffrey ME, Billups K, Bogaev CA, Kassell NF, Lee KS: Detection of soluble E-selectin, ICAM-1, VCAM-1 and L-selectin in the cerebrospinal fluid of patients after subarachnoid hemorrhage. Journal of Neurosurgery 89:559-567,1998.Entrez PubMed 9761049
^ Frijns CJM, Kappelle LJ: Inflammatory Cell Adhesion Molecules in Ischemic Cerebrovascular Disease. Stroke 33:2115-2122,2002. Entrez PubMed 12154274