Human Genome Diversity Project

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The Human Genome Diversity Project (HGDP) was started by Stanford University's Morrison Institute and a collaboration of scientists around the world. The HGDP is in no way related to the Human Genome Project, and has attempted to maintain a completely distinct identity. Unlike the latter, which has attempted to map the entire human genome, the HGDP has attempted to map the DNA that varies between humans, which is a less than 1 % difference.

1 Potential benefits
2 Current status
3 Alternative approaches
4 Potential problems
5 External links

[edit] Potential benefits

Members of the HGDP have maintained that diversity research could yield new data on various fields of study ranging from disease surveillance to anthropology. The Morrison Institute has maintained that diversity research could create definitive proof of the origin of individual racial groups.

Another potential gain lies in research on human traits. For example, through diversity research one can identify the causes of a long or short nose and how such characteristics relate to racial groups and finally how individual racial characteristics are part of a pattern of human development. The HGDP has maintained that research needs to be conducted as quickly as possible before small native populations in places like South America become extinct. HGDP scientists have argued that if we are to ever gain a full assessment of human development, we must engage in diversity research immediately.

Finally, one last benefit is disease research. Diversity research could unlock secrets behind the vulnerability of racial groups to certain diseases and how populations have adapted to these vulnerabilities (see race in biomedicine). The HGDP could help medical researchers create strategies to deal with these issues.

[edit] Current status

Despite reports that the HGDP halted and that protests from organizations like The ETC Group and other NGOs drained support for the HGDP, including Stanford University's Morrison Institute shutting down all research, and that the HGDP is over and will never be completed in its current form, research did continue. The Archaeological Institute of America (Archaeology, May/June 2006, Volume 59, Number 3, page 48) reports on a representative world distribution of genetic ancestry, 52 distinct genetic markers, concluded by HGDP research:

Africa	Asia			Europe
Bantu	Ctrl/South	Eastern Asia		Adygei
Biaka	Balochi	Cambodian	Mongola	Basque
Mandenka	Brahui	Dai	Naxi	French
Mbuti pygmy	Burusho	Daur	Oroqen	North Italian
Mozabite	Hazara	Han (N. China)	She	Orcadian
San	Kalash	Han (S. China)	Tu	Russian
Yoruba	Makrani	Hezhen	Tujia	Sardinian
	Pathan	Japanese	Xibo	Tuscan
	Sindhi	Lahu	Yakut
Native America	Uygur	Miao	Yi
Colombian				Oceania
Karitiana	Western Asia			Melanesian
Maya	Bedouin			Papuan
Pima	Druze
Surui

[edit] Alternative approaches

In 1995, the National Research Council (NRC) issued its recommendations on the subject. While the NRC endorsed the concept of diversity research, it criticized the HGDP's procedure. The NRC claimed that the HGDP had too many ethical lapses and problems. The NRC report suggested several alternatives such as doing sampling anonymously (i.e. sampling genetic data without tying it to specific racial groups). While such approaches would eliminate the concerns discussed below (regarding racism, weapons development, etc.), it would also prevent researchers from achieving many of the benefits that were to be gained from the project.

Some members of the Human Genome Project (HGP) had argued in favor of engaging in diversity research on data gleaned from the Human Genome Project. Most agreed that if diversity research was to happen, it should only be in conjunction with the HGP and not as a separate project.

A number of the principal collaborators with the HGDP have been involved in the privately-funded Genographic Project launched in April 2005 with similar aims.

[edit] Potential problems

[edit] Racism

One major concern with the research project has been the potential for racism in certain countries resulting from HGDP data. Some have speculated that when governments are armed with genetic data linked to certain racial groups, they could feel the need to deny people rights based on this data. For example, countries could define races purely in genetic terms and deny a certain person right(s) based on their lack of conformity to a certain race's "genetic model."

The ETC Group (formerly RAFI) has been a major critic of the HGDP citing issues of racism and stigmatization that could occur should the HGDP be completed.

[edit] Biological weapons

Another concern with the HGDP has been the threat of racially targeted biological weapons from the project. Since the project will identify genes that tend to conform to specific racial groups, many have theorized that groups could create biological weapons that could target specific racial groups. Should the HGDP uncover specific diseases that tend to affect certain races, it is conceivable that a groups could develop a biological weapon that targets that certain disease and killing that specific racial group only. While most have called these ideas ridiculous, many concede that such weapons are theoretically possible and could have a dire impact.

[edit] Criticism

8 of 9 DNA groups under Ctrl/South category belong to Pakistan even though India is in the same group with about 7 times the population of Pakistan and with racial diversities many times over.