Protein:HSD11B1
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hydroxysteroid (11-beta) dehydrogenase 1
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| Identifiers | |
| Symbol | HSD11B1 HSD11B, HSD11 |
| HUGO | 5208 |
| Entrez | 3290 |
| OMIM | 600713 |
| RefSeq | NM_005525 |
| UniProt | P28845 |
| Other data | |
| EC number | 1.1.1.146 |
| Locus | Chr. 1 q32-q41 |
Protein:HSD11B1 (also known as 11β-hydroxysteroid dehydrogenase type 1) is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system.
In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors.
It is inhibited by carbenoxolone, a drug typically used in thre treatment of peptic ulcers.
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Carbohydrate dehydrogenases - Lactate dehydrogenase - Malate dehydrogenase - Isocitrate dehydrogenase - Phosphogluconate dehydrogenase - Glucose-6-phosphate dehydrogenase
Hydroxysteroid dehydrogenase: 11 Beta (HSD11B1, HSD11B2) - 3 Beta (3-beta-HSD) - 17 Beta
Glucose oxidase - L-gulonolactone oxidase - Xanthine oxidase
