Hot 100 number-one hits of 2006 (USA)
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This is a list of the U.S. Billboard magazine Hot 100 number-ones of 2006.
| Issue Date | Song | Artist |
| January 7 | Don't Forget About Us | Mariah Carey |
| January 14 | Laffy Taffy | D4L |
| January 21 | Grillz | Nelly featuring Paul Wall, Ali and Gipp |
| January 28 | Grillz | Nelly featuring Paul Wall, Ali and Gipp |
| February 4 | Check on It | Beyoncé featuring Slim Thug |
| February 11 | Check on It | Beyoncé featuring Slim Thug |
| February 18 | Check on It | Beyoncé featuring Slim Thug |
| February 25 | Check on It | Beyoncé featuring Slim Thug |
| March 4 | Check on It | Beyoncé featuring Slim Thug |
| March 11 | You're Beautiful | James Blunt |
| March 18 | So Sick | Ne-Yo |
| March 25 | So Sick | Ne-Yo |
| April 1 | Temperature | Sean Paul |
| April 8 | Bad Day | Daniel Powter |
| April 15 | Bad Day | Daniel Powter |
| April 22 | Bad Day | Daniel Powter |
| April 29 | Bad Day | Daniel Powter |
| May 6 | Bad Day | Daniel Powter |
| May 13 | SOS | Rihanna |
| May 20 | SOS | Rihanna |
| May 27 | SOS | Rihanna |
| June 3 | Ridin' | Chamillionaire featuring Krayzie Bone |
| June 10 | Ridin' | Chamillionaire featuring Krayzie Bone |
| June 17 | Hips Don't Lie | Shakira featuring Wyclef Jean |
| June 24 | Hips Don't Lie | Shakira featuring Wyclef Jean |
| July 1 | Do I Make You Proud | Taylor Hicks |
| July 8 | Promiscuous | Nelly Furtado featuring Timbaland |
| July 15 | Promiscuous | Nelly Furtado featuring Timbaland |
| July 22 | Promiscuous | Nelly Furtado featuring Timbaland |
| July 29 | Promiscuous | Nelly Furtado featuring Timbaland |
| August 5 | Promiscuous | Nelly Furtado featuring Timbaland |
| August 12 | Promiscuous | Nelly Furtado featuring Timbaland |
| August 19 | London Bridge | Fergie |
| August 26 | London Bridge | Fergie |
| September 2 | London Bridge | Fergie |
| September 9 | SexyBack | Justin Timberlake |
| September 16 | SexyBack | Justin Timberlake |
| September 23 | SexyBack | Justin Timberlake |
| September 30 | SexyBack | Justin Timberlake |
| October 7 | SexyBack | Justin Timberlake |
| October 14 | SexyBack | Justin Timberlake |
| October 21 | SexyBack | Justin Timberlake |
| October 28 | Money Maker | Ludacris featuring Pharrell |
| November 4 | Money Maker | Ludacris featuring Pharrell |
| November 11 | My Love | Justin Timberlake featuring T.I. |
| November 18 | My Love | Justin Timberlake featuring T.I. |
| November 25 | My Love | Justin Timberlake featuring T.I. |
| December 2 | I Wanna Love You | Akon featuring Snoop Dogg |
| December 9 | I Wanna Love You | Akon featuring Snoop Dogg |
| December 16 | Irreplaceable | Beyoncé |
| December 23 | Irreplaceable | Beyoncé |
| December 30 | Irreplaceable | Beyoncé |
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