Hot 100 number-one hits of 2005 (USA)
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This is a list of the U.S. Billboard magazine Hot 100 number-ones of 2005.
| Issue Date | Song | Artist |
| January 1 | Let Me Love You | Mario |
| January 8 | Let Me Love You | Mario |
| January 15 | Let Me Love You | Mario |
| January 22 | Let Me Love You | Mario |
| January 29 | Let Me Love You | Mario |
| February 5 | Let Me Love You | Mario |
| February 12 | Let Me Love You | Mario |
| February 19 | Let Me Love You | Mario |
| February 26 | Let Me Love You | Mario |
| March 5 | Candy Shop | 50 Cent featuring Olivia |
| March 12 | Candy Shop | 50 Cent featuring Olivia |
| March 19 | Candy Shop | 50 Cent featuring Olivia |
| March 26 | Candy Shop | 50 Cent featuring Olivia |
| April 2 | Candy Shop | 50 Cent featuring Olivia |
| April 9 | Candy Shop | 50 Cent featuring Olivia |
| April 16 | Candy Shop | 50 Cent featuring Olivia |
| April 23 | Candy Shop | 50 Cent featuring Olivia |
| April 30 | Candy Shop | 50 Cent featuring Olivia |
| May 7 | Hollaback Girl | Gwen Stefani |
| May 14 | Hollaback Girl | Gwen Stefani |
| May 21 | Hollaback Girl | Gwen Stefani |
| May 28 | Hollaback Girl | Gwen Stefani |
| June 4 | We Belong Together | Mariah Carey |
| June 11 | We Belong Together | Mariah Carey |
| June 18 | We Belong Together | Mariah Carey |
| June 25 | We Belong Together | Mariah Carey |
| July 2 | Inside Your Heaven | Carrie Underwood |
| July 9 | We Belong Together | Mariah Carey |
| July 16 | We Belong Together | Mariah Carey |
| July 23 | We Belong Together | Mariah Carey |
| July 30 | We Belong Together | Mariah Carey |
| August 6 | We Belong Together | Mariah Carey |
| August 13 | We Belong Together | Mariah Carey |
| August 20 | We Belong Together | Mariah Carey |
| August 27 | We Belong Together | Mariah Carey |
| September 3 | We Belong Together | Mariah Carey |
| September 10 | We Belong Together | Mariah Carey |
| September 17 | Gold Digger | Kanye West featuring Jamie Foxx |
| September 24 | Gold Digger | Kanye West featuring Jamie Foxx |
| October 1 | Gold Digger | Kanye West featuring Jamie Foxx |
| October 8 | Gold Digger | Kanye West featuring Jamie Foxx |
| October 15 | Gold Digger | Kanye West featuring Jamie Foxx |
| October 22 | Gold Digger | Kanye West featuring Jamie Foxx |
| October 29 | Gold Digger | Kanye West featuring Jamie Foxx |
| November 5 | Gold Digger | Kanye West featuring Jamie Foxx |
| November 12 | Gold Digger | Kanye West featuring Jamie Foxx |
| November 19 | Gold Digger | Kanye West featuring Jamie Foxx |
| November 26 | Run It! | Chris Brown |
| December 3 | Run It! | Chris Brown |
| December 10 | Run It! | Chris Brown |
| December 17 | Run It! | Chris Brown |
| December 24 | Run It! | Chris Brown |
| December 31 | Don't Forget About Us | Mariah Carey |
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