Hot 100 number-one hits of 1980 (USA)
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These are the Billboard magazine Hot 100 number one hits of 1980.
| Issue Date | Song | Artist |
| January 5 | Please Don't Go | KC and the Sunshine Band |
| January 12 | Escape (The Piña Colada Song) | Rupert Holmes |
| January 19 | Rock with You | Michael Jackson |
| January 26 | Rock with You | Michael Jackson |
| February 2 | Rock with You | Michael Jackson |
| February 9 | Rock with You | Michael Jackson |
| February 16 | Do That to Me One More Time | Captain & Tennille |
| February 23 | Crazy Little Thing Called Love | Queen |
| March 1 | Crazy Little Thing Called Love | Queen |
| March 8 | Crazy Little Thing Called Love | Queen |
| March 15 | Crazy Little Thing Called Love | Queen |
| March 22 | Another Brick in the Wall (Part II) | Pink Floyd |
| March 29 | Another Brick in the Wall (Part II) | Pink Floyd |
| April 5 | Another Brick in the Wall (Part II) | Pink Floyd |
| April 12 | Another Brick in the Wall (Part II) | Pink Floyd |
| April 19 | Call Me | Blondie |
| April 26 | Call Me | Blondie |
| May 3 | Call Me | Blondie |
| May 10 | Call Me | Blondie |
| May 17 | Call Me | Blondie |
| May 24 | Call Me | Blondie |
| May 31 | Funkytown | Lipps Inc |
| June 7 | Funkytown | Lipps Inc |
| June 14 | Funkytown | Lipps Inc |
| June 21 | Funkytown | Lipps Inc |
| June 28 | Coming Up (Live at Glasgow) | Paul McCartney and Wings |
| July 5 | Coming Up (Live at Glasgow) | Paul McCartney and Wings |
| July 12 | Coming Up (Live at Glasgow) | Paul McCartney and Wings |
| July 19 | It's Still Rock and Roll to Me | Billy Joel |
| July 26 | It's Still Rock and Roll to Me | Billy Joel |
| August 2 | Magic | Olivia Newton-John |
| August 9 | Magic | Olivia Newton-John |
| August 16 | Magic | Olivia Newton-John |
| August 23 | Magic | Olivia Newton-John |
| August 30 | Sailing | Christopher Cross |
| September 6 | Upside Down | Diana Ross |
| September 13 | Upside Down | Diana Ross |
| September 20 | Upside Down | Diana Ross |
| September 27 | Upside Down | Diana Ross |
| October 4 | Another One Bites the Dust | Queen |
| October 11 | Another One Bites the Dust | Queen |
| October 18 | Another One Bites the Dust | Queen |
| October 25 | Woman in Love | Barbra Streisand |
| November 1 | Woman in Love | Barbra Streisand |
| November 8 | Woman in Love | Barbra Streisand |
| November 15 | Lady | Kenny Rogers |
| November 22 | Lady | Kenny Rogers |
| November 29 | Lady | Kenny Rogers |
| December 6 | Lady | Kenny Rogers |
| December 13 | Lady | Kenny Rogers |
| December 20 | Lady | Kenny Rogers |
| December 27 | (Just Like) Starting Over | John Lennon |
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