Hot 100 number-one hits of 1959 (USA)
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These are the Billboard magazine Hot 100 number one hits of 1959.
| Issue Date | Song | Artist |
| January 5 | The Chipmunk Song (Christmas Don't Be Late) | David Seville and The Chipmunks |
| January 12 | The Chipmunk Song (Christmas Don't Be Late) | David Seville and The Chipmunks |
| January 19 | Smoke Gets in Your Eyes | The Platters |
| January 26 | Smoke Gets in Your Eyes | The Platters |
| February 2 | Smoke Gets in Your Eyes | The Platters |
| February 9 | Stagger Lee | Lloyd Price |
| February 16 | Stagger Lee | Lloyd Price |
| February 23 | Stagger Lee | Lloyd Price |
| March 2 | Stagger Lee | Lloyd Price |
| March 9 | Venus | Frankie Avalon |
| March 16 | Venus | Frankie Avalon |
| March 23 | Venus | Frankie Avalon |
| March 30 | Venus | Frankie Avalon |
| April 6 | Venus | Frankie Avalon |
| April 13 | Come Softly to Me | The Fleetwoods |
| April 20 | Come Softly to Me | The Fleetwoods |
| April 27 | Come Softly to Me | The Fleetwoods |
| May 4 | Come Softly to Me | The Fleetwoods |
| May 11 | The Happy Organ | Dave "Baby" Cortez |
| May 18 | Kansas City | Wilbert Harrison |
| May 25 | Kansas City | Wilbert Harrison |
| June 1 | The Battle of New Orleans | Johnny Horton |
| June 8 | The Battle of New Orleans | Johnny Horton |
| June 15 | The Battle of New Orleans | Johnny Horton |
| June 22 | The Battle of New Orleans | Johnny Horton |
| June 29 | The Battle of New Orleans | Johnny Horton |
| July 6 | The Battle of New Orleans | Johnny Horton |
| July 13 | Lonely Boy | Paul Anka |
| July 20 | Lonely Boy | Paul Anka |
| July 27 | Lonely Boy | Paul Anka |
| August 3 | Lonely Boy | Paul Anka |
| August 10 | A Big Hunk o' Love | Elvis Presley |
| August 17 | A Big Hunk o' Love | Elvis Presley |
| August 24 | The Three Bells | The Browns |
| August 31 | The Three Bells | The Browns |
| September 7 | The Three Bells | The Browns |
| September 14 | The Three Bells | The Browns |
| September 21 | Sleep Walk | Santo & Johnny |
| September 28 | Sleep Walk | Santo & Johnny |
| October 5 | Mack the Knife | Bobby Darin |
| October 12 | Mack the Knife | Bobby Darin |
| October 19 | Mack the Knife | Bobby Darin |
| October 26 | Mack the Knife | Bobby Darin |
| November 2 | Mack the Knife | Bobby Darin |
| November 9 | Mack the Knife | Bobby Darin |
| November 16 | Mr. Blue | The Fleetwoods |
| November 23 | Mack the Knife | Bobby Darin |
| November 30 | Mack the Knife | Bobby Darin |
| December 7 | Mack the Knife | Bobby Darin |
| December 14 | Heartaches by the Number | Guy Mitchell |
| December 21 | Heartaches by the Number | Guy Mitchell |
| December 28 | Why | Frankie Avalon |
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1940 | 1941 | 1942 | 1943 | 1944 | 1945 | 1946 | 1947 | 1948 | 1949 |
