Homogeneously staining region

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Homogeneously staining region (also HSR) is one type of change in a chromosome's structure which is frequently observed in the nucleus of human cancer cells. In the region of a chromosome where a HSR occurs, a segment of the chromosome, which presumably contains a gene or genes that give selective advantage to the progression of the cancer, is amplified or duplicated many times. As a result of the duplication this chromosomal segment is greatly lengthened and expanded such that when it is stained with a fluorescent probe specific to the region (Fluorescent in situ hybridization), rather than causing a focal fluorescent signal as in a normal chromosome, the probe "paints" a broad fluorescent signal over the whole of the amplified region. It is because of the appearance of this broadly staining region that this chromosomal abnormality was named a homogeneously staining region.

[edit] References

• Biedler JL, Spengler BA: Metaphase chromosome anomaly: association with drug resistance and cell-specific products. Science 1976, 191(4223):185-7.