HLA-C
From Wikipedia, the free encyclopedia
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major histocompatibility complex, class I, C
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| Identifiers | |
| Symbol | HLA-C |
| HUGO | 4933 |
| Entrez | 3107 |
| OMIM | 142840 |
| RefSeq | NM_002117 |
| UniProt | P30499 |
| Other data | |
| Locus | Chr. 6 p21.31 |
HLA-C belongs to the MHC (human = HLA) class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.
HLA-C is a locus on chromosome 6 that encodes for a large number of HLA-C alleles that are Class-I MHC receptors. HLA-C is localized proximal to the HLA-B locus is located on the distal end of the HLA region. Most HLA Cw:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.
Contents |
[edit] Disease Associations
[edit] By Serotype
Cw1: Multinodular goiters[1]
[edit] By Allele
Cw*16: B chronic lymphocytic leukaemia[2]
[edit] Nomenclature
Cw*01
- Cw1 Serotype: Cw*0102 and Cw*0109
- Cw11 ?
- Cw*0104 to *0108
Cw*02
- Cw2 Serotype: Cw*0202 and *0208
- Cw*0203 to *0207, and 0209
Cw*03
- Cw9 Serotype: Cw*0303
- Cw10 Serotype: Cw*0302, *0304, and *0306
- Cw3 Serotype: Cw*0307
- Cw*0305 and 0308
Cw*04
- Cw4 Serotype: Cw*0401, *0407, and *0410
Cw*05
- Cw5 Sertoype: Cw*0501 and *0502
- Cw*0503 to *506 and *0508 to *0510
Cw*06
- Cw6 Serotype: Cw*0602 and *0605
- Cw6*0603, *0604 and *0606 to *0611
- Cw7 Serotype: Cw*0701 to *0706, *0712, *0714, *0716
- Cw*0707 to *0711, *0713, *0715, and *0717 to *0729
Cw*08
- Cw8 Serotype: Cw*0801, *0802 and *0803
- Cw*805 to *0812
Cw*1202 to *1215
Cw*1402 to *1405
Cw*1501 to *1511
Cw*1601 to *1606
Cw*1701 to *1703
Cw*1801 and *1802
[edit] Common Haplotype
Cw4-B35 (Western Africa to Native Americans) Cw7-B7 (Western Eurasia, South Africa) Cw7-B8 (Western Eurasia) Cw1-B46 (China, Indochina) Cw5-B44 (Western Eurasia)
[edit] References
- ^ Ríos A, Rodríguez J, Moya M, Galindo P, Canteras M, Alvarez M, Parrilla P (2006). "Associations of HLA-C alleles with multinodular goiters: study in a population from southeastern Spain.". Arch Surg 141 (2): 123-8. PMID 16490887.
- ^ Montes-Ares O, Moya-Quiles M, Montes-Casado M, Guerra-Pérez N, Campillo J, González C, López-Bermejo A, Tamayo M, Majado M, Parrado A, Muro M, Marín L, Alvarez-López M (2006). "Human leucocyte antigen-C in B chronic lymphocytic leukaemia.". Br J Haematol 135 (4): 517-9. PMID 17054674.
