Talk:High density lipoprotein

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Antioxident suppliments block the response of HDL to Simvastatin-Niacin Therapy (Cheung, Zhao, Chait, Albers, Brown - Arterioscler Thromb Vasc Biol. 2001; 21:1320-1326.)

Antioxident combo used was 12.5mg beta carotine, 500mg vitimin C, 400 IU vitimin E and 50 mg of selenium.

HDL increase from statin+niacin therapy was reduced 33% (+25% to +18%) when the antioxidents were added to the statin/niacin therapy.

NIH HATS s(HDL Atherosclerosis Treatment Study) confirmed this observation. Niacin HDL effect reduced from +30% to +20% with antioxidents. Major effect on HDL2. Physical evidence noted in Angiographic and clinical events during study.

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I believe cortisol is produced in the adrenal cortex (not in the liver as the article currently states).

Contents 1 Cat 2 toxic level? 3 Large vs small HDL 4 Restructuring 5 Niacin versus Niacinamide

[edit] Cat

Every article can be classsified more than one way. So, it is with a lot of mainstream activities like exercise, diet, and even HDL. They are part of natural approaches to health such as Natural hygiene which is classified alternative medicine. I have replaced the orange box with one that doesn't even look like a box. -- John Gohde 07:47, 2 Jun 2004 (UTC)

It'd be nice to get a list of the foods that are high-density lipoprotein (HDL)

Well, HDL is not in foods. It is only a lipid particle in the body. Some foods influence HDL levels. Those may indeed be listed. JFW | T@lk 04:50, 28 November 2005 (UTC)

Is it important to mention that drinking more than 1-2 cups, or even that amount in certain individuals, may lead to heart problems? (reference 3) C3045051 04:47, 19 August 2006 (UTC)

[edit] toxic level?

Is there a point where the blood HDL level is considered too high or toxic? KBi 01:50, 1 December 2005 (UTC)

Not to my knowledge. JFW | T@lk 01:58, 1 December 2005 (UTC)

What is as important as HDL level is HDL function. Is the excess choelsterol in the artery plaque been taken away to be eliminated? Des HDL that has picked up this excess cholesterol deliver it to liver for elimination? The critical issue is that 40% of individuals who develope clinical event (such as a hear attack or stroke) have normal LEVELS of HDL. One reason they still develope clinical event is that their HDL is old. It has not delivered its load to the liver and can not pick up excess cholesterol from artery walll.

1) What exactly triggers a loaded HDL molecule to release its cholesterol load?

2) Is it possible to create injectable HDL (like insulin)? Bioengineer some bacterium to squirt it out?

JeramieHicks

[edit] Large vs small HDL

This claim that the "large" HDL correlates better with clinical outcomes than "small" HDL. Is there a reference for that? --Slashme 17:33, 15 January 2006 (UTC)

Sure. "for HDL, H5-1, with H5, H4, and H3 being the largest particles... H5, H4, and H3, are negatively associated with coronary artery disease, whereas H2 and H1 are positively associtaed with coronary artery disease." Kwiterovich PO. The Metabolic Pathways of High-Density Lipoprotein, Low-Density Lipoprotein, and Triglycerides: A Current Review. Am J Cardiol 2000;86(suppl):5L.

Ulgo 00:27, 3 April 2006 (CET)

[edit] Restructuring

I did a major restructuring, including a separate section for "Structure and Function", and adding info about treatment and references. I respectfully removed the unverified Oxford trial comment, since it can be misunderstood of even taken out of context. Carloseduardo 15:59, 30 December 2006 (UTC)

[edit] Niacin versus Niacinamide

Niacin, (which can lead to "flushing" of the skin), has been proven to raise HDL. Does anyone know if Niacinamide, (a form of niacin, which is ofter found in vitamin supplements, and does not cause "flushing" of the skin), has been tested to see if it raises HDL, and if so, what were the results?204.80.61.10 21:25, 11 January 2007 (UTC)Bennett Turk

It would appear that Niacinamide will not raise "good" HDL or lower "bad" LDL. Too bad since Niacinamide is found in most B-vitamin supplements, as well as most multi-vitamins sold in stores.24.195.255.68 00:00, 29 January 2007 (UTC)Bennett Turk